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(-)-demecolcine

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Origin: China

Cas No: 477-30-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 477-30-5 Formula: C21H25NO5 Molecular Weight: 371.42700

    Description

    An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

    Basic Info

    Chemical Name (-)-demecolcine
    Synonyms

    Demecolcine;
    N-Deacetyl-N-methylcolchicine;

    CAS No. 477-30-5
    Molecular Formula C21H25NO5
    Molecular Weight 371.42700
    PSA 66.02000
    LogP 3.34580

    Properties

    Density 1.21g/cm3
    Boiling Point 625.5ºC at 760mmHg
    Melting Point 73-75ºC
    Flash Point 332.1ºC
    Refractive Index 1.582
    Storage Condition 2-8ºC
    Vapor Pressure 1.46E-15mmHg at 25°C

    Safety Info

    RTECS GH0800000
    Hazard Class 6.1(a)
    Packing Group II
    WGK Germany 3
    RIDADR UN 2811
    Risk Statements R25
    Hazard Codes T

    Synthesis Route

    N-methyl-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]formamide→(-)-demecolcine
    Colchicine→(-)-demecolcine
    Colchiceine→(-)-demecolcine

    Precursor

    Colchiceine
    Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-1,2,3,10-tetramethoxy-, (7S)-
    N-Deacetyl Colchiceine
    N-methyl-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]formamide

    Downstream Product

    N-methyl-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]formamide
    N-methyl-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
    Speciosine
    (7S)-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one

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