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Home > All categories> Biochemicals and Pharmaceutical Chemicals> Pharmaceutical Impurities> 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]imidazole
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1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]imidazole

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Origin: China

Cas No: 27523-40-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

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    CAS No.: 27523-40-6 Formula: C18H14Cl4N2O Molecular Weight: 416.12900

    Description

    Isoconazole is an azole antifungal drug and could inhibit gram positive bacteria. Nigerian and British medical researchers found that for foot and vaginal infections, isoconazole has a similar effectiveness to clotrimazole. Isoconazole nitrate may be used in combination with corticosteroid diflucortolone to increase its bioavailability.

    Basic Info

    Chemical Name 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]imidazole
    Synonyms

    Isoconazol;
    Fazol;
    Travogen;
    Isoconazole;
    Isoconazolum;

    CAS No. 27523-40-6
    Molecular Formula C18H14Cl4N2O
    Molecular Weight 416.12900
    PSA 27.05000
    LogP 6.45480

    Properties

    Appearance & Physical State COA
    Density 1.4g/cm3
    Boiling Point 555.1ºC at 760mmHg
    Flash Point 289.5ºC
    Refractive Index 1.625
    Vapor Pressure 8.55E-12mmHg at 25°C

    Synthesis Route

    2-bromo-2’,4’-dichloroacetophenone→1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]imidazole
    2,2',4'-Trichloroacetophenone→1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]imidazole
    1-(2,4-dichlorophenyl)-2-imidazol-1-ylethanone→1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]imidazole

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Intraperitoneal LD50 - Lethal dose, 50 percent kill Rodent - mouse 189 mg/kg 1.Details of toxic effects not reported other than lethal dose value

    Precursor

    2-bromo-2’,4’-dichloroacetophenone
    2-bromo-1-(2,4-dichlorophenyl)ethanol
    2,2',4'-Trichloroacetophenone
    1-(2,4-dichlorophenyl)-2-imidazol-1-ylethanone

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