Home > Organophosphorus Compounds> 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE

1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE

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Origin: China

Cas No: 4004-05-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 4004-05-1 Formula: C41H78NO8P Molecular Weight: 744.03400

Description

1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE) is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions. DOPE can be used as an emulsifier to facilitate DNA-liposome complex transport across membranes. It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.

Basic Info

Chemical Name	1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE
Synonyms	DOPE; Dioleoyl phosphoethanolamine; L-A-phosphatidylethanolamine dioleoyl; 1,2-dioleoyl-sn-glycero-3-phosphatidylethanolamine; 1,2-dioleoyl-sn-glycerol-3-phosphoethanolamine; 3-SN-PHOSPHATIDYLETHANOLAMINE,1,2-DIDEOYL; 1,2-di-O-oleoyl-sn-glycero-3-phosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE); 1,2-dioleoyl-sn-glycero-3-phosphoethanoloamine; COATSOME ME-8181 (DOPE); DIOLEOYL PHOSPHATIDYL ETHANOLAMINE; 18:1 PE;
CAS No.	4004-05-1
Molecular Formula	C41H78NO8P
Molecular Weight	744.03400
PSA	144.19000
LogP	12.30900

Properties

Appearance & Physical State	lyophilized powder
Density	1.008g/cm3
Boiling Point	759.221ºC at 760 mmHg
Flash Point	412.962ºC
Refractive Index	1.484
Storage Condition	-20ºC
Vapor Pressure	0mmHg at 25°C

Safety Info

Safety Statements	36/37
HS Code	2931900090
RIDADR	UN 1888
Risk Statements	R22; R38; R40; R48/20/22
Hazard Codes	Xn
Hazard Declaration	H302; H315; H319; H331; H336; H351; H361d; H372
Symbol	GHS06, GHS08
Caution Statement	P261; P281; P305 + P351 + P338; P311
Signal Word	Danger

Synthesis Route

1,2-dioleoyl-sn-glycero-3-phosphocholine+ethanolamine→1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE
(S)-3-(3,4-Dimethoxybenzyloxy)propane-1,2-diyl Dioleate→1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE
1,2-dioleoyl-sn-glycerol+ethanolamine→1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE

Precursor

1,2-dioleoyl-sn-glycero-3-phosphocholine
1,2-dioleoyl-sn-glycerol
oleic acid anhydride
(S)-3-(3,4-Dimethoxybenzyloxy)propane-1,2-diyl Dioleate

Downstream Product

(R)-1,2-distearoylphosphatidylethanolamine

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