Home > All categories> Biochemicals and Pharmaceutical Chemicals> Pharmaceutical Impurities> [2-[(8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate

[2-[(8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate

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Origin: China

Cas No: 7753-60-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 7753-60-8 Formula: C23H30O5 Molecular Weight: 386.48100

Description

Anecortave (rINN) is a novel angiogenesis inhibitor used in the treatment of the exudative (wet) form of age-related macular degeneration. Although based on a steroid nucleus, which can be derived from cortisol, it possesses little glucocorticoid activity. It will be marketed by Alcon as anecortave acetate for depot suspension under the trade name Retaane.

Basic Info

Chemical Name	[2-[(8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
Synonyms	Retaane; AL-3789; 21-Acetoxy-17-hydroxy-pregna-4,9(11)-dien-3,20-dion; Anecortave acetate; Retaane suspension; 2-((10S,13S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate; 2-((8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate; Anecortave; 21-acetoxy-17-hydroxy-pregna-4,9(11)-diene-3,20-dione;
CAS No.	7753-60-8
Molecular Formula	C23H30O5
Molecular Weight	386.48100
PSA	80.67000
LogP	3.30170

Properties

Density	1.23g/cm3
Boiling Point	551.8ºC at 760 mmHg
Flash Point	188.4ºC
Refractive Index	1.572

Synthesis Route

cortisol 21-acetate→[2-[(8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
21-chloro-17-hydroxy-pregna-4,9(11)-diene-3,20-dione→[2-[(8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
21-bromo-17-hydroxy-pregna-4,9(11)-diene-3,20-dione→[2-[(8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate

Precursor

21-Acetoxy-9α-bromo-11β-fluoro-17α-hydroxy-4-pregnene-3,20-dione
Nicotinic acid (8S,10S,13S,14S,17R)-17-(2-acetoxy-acetyl)-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester
cortisol 21-acetate
21-bromo-17-hydroxy-pregna-4,9(11)-diene-3,20-dione

Downstream Product

9,11β-epoxy-17,21-dihydroxy-9β-pregn-4-ene-3,20-dione
(8S,10S,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one
fludrocortisone acetate
fludrocortisone

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