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2,6-Dichloronicotinic acid

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Origin: China

Cas No: 38496-18-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 38496-18-3 Formula: C6H3Cl2NO2 Molecular Weight: 192.00000

Description

Used for preparation of pyridine derivatives as inhibitors of human 11β hydroxysteroid dehydrogenase type 1 enzyme.

Basic Info

Chemical Name	2,6-Dichloronicotinic acid
Synonyms	2,6-Dichloro-3-pyridinecarboxylic Acid; 2,6-dichloropyridine-3-carboxylic acid;
CAS No.	38496-18-3
Molecular Formula	C6H3Cl2NO2
Molecular Weight	192.00000
PSA	50.19000
LogP	2.08660

Properties

Appearance & Physical State	off-white to yellow solid
Density	1.612 g/cm3
Boiling Point	351.2ºC at 760 mmHg
Melting Point	140-146ºC
Flash Point	166.2ºC
Refractive Index	1.605

Safety Info

Safety Statements	S26-S36
HS Code	2933399090
WGK Germany	3
Risk Statements	R36/37/38
Hazard Codes	Xi

Synthesis Route

Methanol+2,6-dichloro-3-(trichloromethyl)pyridine→2,6-Dichloronicotinic acid+6-Chloro-2-methoxynicotinic acid
2,6-Dichloropyridine→2,6-Dichloronicotinic acid
2,6-Dichloropyridine+carbon dioxide→2,6-Dichloronicotinic acid

Precursor

2,6-Dichloropyridine
2,6-dichloro-3-(trichloromethyl)pyridine
carbon dioxide
2,6-dihydroxy-nicotinic acid ethyl ester

Downstream Product

2-Chloro-6-phenylnicotinonitrile
6-Chloro-2-methoxynicotinic acid
2,6-Dimethoxypyridine-3-carboxylic acid
7-chloro-1H-pyrido[2,3-d]pyrimidine-2,4-dione

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