Home > Chiral Compounds> (2R,5R)-5-Hydroxy-1,3-oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester

(2R,5R)-5-Hydroxy-1,3-oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester

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Origin: China

Cas No: 147126-62-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 147126-62-3 Formula: C14H24O4S Molecular Weight: 288.40300

Description

Lamivudine intermediate.

Basic Info

Chemical Name	(2R,5R)-5-Hydroxy-1,3-oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester
Synonyms	L-menthyl 5R-hydroxy-1,3-oxathiolane-2R-carboxylate;
CAS No.	147126-62-3
Molecular Formula	C14H24O4S
Molecular Weight	288.40300
PSA	81.06000
LogP	2.39830

Properties

Density	1.16
Boiling Point	402.3ºC at 760 mmHg
Refractive Index	1.527

Synthesis Route

p-Dithiane-2,5-diol+L-Menthyl glyoxylate hydrate→(2R,5R)-5-Hydroxy-1,3-oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester

Precursor

p-Dithiane-2,5-diol
L-Menthyl glyoxylate hydrate

Downstream Product

(2R,5S)-L-Methyl-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate
[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] (2R,5S)-5-acetyloxy-1,3-oxathiolane-2-carboxylate
[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] (2R,5R)-5-acetyloxy-1,3-oxathiolane-2-carboxylate

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(2R,5R)-5-Hydroxy-1,3-oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester

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