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4-(Hydroxymethyl)benzoic acid

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Origin: China

Cas No: 3006-96-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 3006-96-0 Formula: C8H8O3 Molecular Weight: 152.14700

Description

4-(Hydroxymethyl)benzoic Acid is an intermediate in the synthesis of Eprosartan, a prototype of the imidazoleacrylic acid angiotensin II receptor antagonists used as an antihypertensive agent.

Basic Info

Chemical Name	4-(Hydroxymethyl)benzoic acid
Synonyms	4-(Hydroxymethyl)benzoic Acid; hb linker; para-hydroxymethylbenzoic acid; 4-Hydroxythylbenzoic acid; 4-(hydroxymethyl)-benzoic acid; 4-carboxy-benzyl alcohol; HMBA Linker; 4-methylolbenzoic acid; p-methylolbenzoic acid; p-(hydroxymethyl)-benzoic acid; Benzoic acid,4-(hydroxymethyl); 4-Hydroxymethylbenzoic Acid; Hydroxymethylbenzoicacid;
CAS No.	3006-96-0
Molecular Formula	C8H8O3
Molecular Weight	152.14700
PSA	57.53000
LogP	0.87710

Properties

Appearance & Physical State	White to off white powder
Density	1.314 g/cm3
Boiling Point	347.4ºC at 760 mmHg
Melting Point	182-185ºC
Flash Point	178.1ºC
Refractive Index	1.6
Storage Condition	2-8ºC

Safety Info

Safety Statements	S26-S36
HS Code	2918199090
Risk Statements	R36/37/38
Hazard Codes	Xi

Synthesis Route

4-Formylbenzoic acid+→4-(Hydroxymethyl)benzoic acid+4-(anilinomethyl)benzoic acid
p-toluic acid+trifluoroacetic acid→4-(Chloromethyl)benzoic acid+terephthalic acid
4-Formylbenzoic acid→4-(Hydroxymethyl)benzoic acid

Precursor

4-Formylbenzoic acid
p-Xylene
1,4-Benzenedimethanol
acetic acid

Downstream Product

4-(Chloromethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
Methyl 4-(hydroxymethyl)benzoate
1,4-Benzenedimethanol
Methyl 4-(chloromethyl)benzoate

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