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Home > Alcohols> 5-Ethynyl-2′-deoxyuridine, (EdU)
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5-Ethynyl-2′-deoxyuridine, (EdU)

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Origin: China

Cas No: 61135-33-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 61135-33-9 Formula: C11H12N2O5 Molecular Weight: 252.22300

    Description

    5-Ethynyl-2’-deoxyuridine is an extensively used nucleoside analog used as a probe for DNA synthesis. 5-Ethynyl-2’-deoxyuridine is known as an toxic anti-metabolite, which potentially causes DNA instabiliy, necrosis and cell-cycle arrest, therefore it is often used for short-term DNA synthesis in tissue culture and living organisms where prolonged cell survival is not required.

    Basic Info

    Chemical Name 5-Ethynyl-2′-deoxyuridine, (EdU)
    Synonyms

    5-ethynyl-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione;

    CAS No. 61135-33-9
    Molecular Formula C11H12N2O5
    Molecular Weight 252.22300
    PSA 104.55000
    LogP -1.84140

    Properties

    Density 1.55g/cm3
    Refractive Index 1.644

    Synthesis Route

    1-(2-deoxy-β-D-ribofuranosyl)-5-[2-(trimethylsilyl)ethynyl]uracil→5-Ethynyl-2′-deoxyuridine, (EdU)
    5-iodo-2'-deoxyuridine→5-Ethynyl-2′-deoxyuridine, (EdU)
    5-ethynyltrimethylsilyl-3',5'-di-O-p-toluyl-2'-deoxyuridine→5-Ethynyl-2′-deoxyuridine, (EdU)

    Precursor

    1-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-5-iodouracil
    1-(2-deoxy-β-D-ribofuranosyl)-5-[2-(trimethylsilyl)ethynyl]uracil
    5-iodo-2'-deoxyuridine
    5-Ethynyl-3',5'-di-O-p-toluyl-2'-deoxyuridine

    Downstream Product

    5-ethenyl-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
    2-[[5-(5-ethenyl-2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]acetic acid
    5-[2-(4-tert-butylphenyl)ethynyl]-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
    5-acetyl-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

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