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6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole

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Origin: China

Cas No: 84163-77-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 84163-77-9 Formula: C12H13FN2O Molecular Weight: 220.24300

Description

An Intermediate in the synthesis of risperidone and iloperidone.

Basic Info

Chemical Name	6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole
Synonyms	6-fluoro-3-piperidin-4-yl-1,2-benzoxazole;
CAS No.	84163-77-9
Molecular Formula	C12H13FN2O
Molecular Weight	220.24300
PSA	38.06000
LogP	2.76270

Properties

Appearance & Physical State	white crystalline powder
Density	1.216g/cm3
Boiling Point	359ºC at 760 mmHg
Melting Point	59-62ºC
Flash Point	170.9ºC
Refractive Index	1.566
Storage Condition	-20ºC Freezer

Safety Info

RTECS	DL6425000
Safety Statements	S26; S36/37/39
HS Code	2934999090
Risk Statements	R36/37/38
Hazard Codes	Xi
Symbol	GHS06
Signal Word	Danger
Caution Statement	P261; P301 + P310; P305 + P351 + P338
Hazard Declaration	H301; H315; H319; H335

Synthesis Route

(2,4-Difluorophenyl)-4-piperidylmethanone Oxime Hydrochloride→6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole
(2,4-difluorophenyl)-piperidin-4-ylmethanone→6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride→6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole

Precursor

4-(2,4-difluorobenzoyl)piperidine-1-carbaldehyde
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride
(2,4-Difluorophenyl)-4-piperidylmethanone Oxime Hydrochloride
(2,4-difluorophenyl)-piperidin-4-ylmethanone

Downstream Product

Paliperidone
(9R)-3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-7,8-dihydro-6H-pyrido[1,2-a]pyrimidine-4,9-dione
iloperidone

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