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Cetirizine Dihydrochloride

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Origin: China

Cas No: 83881-52-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
83881-52-1
Other Names:
Cetrak
MF:
C21H26Cl2N2O3
EINECS No.:
620-533-8
Place of Origin:
Shaanxi, China
Type:
Antibiotic and Antimicrobial Agents
Grade Standard:
Medicine Grade
Brand Name:
Dideu
Model Number:
USP 39
Purity:
99.9%
Test Standard:
EP 9.0/USP39/BP2015
Content:
99.0% to 101.0%
Test method:
HPLC-ESI-MS
Water:
0.5% Max.
Sulfated ash:
0.1% Max.
Heavy metals:
10ppm Max
Total Impurity:
0.5% Max.
Total plate count:
≤1000cfu/g
Yeast and Moulds:
≤100cfu/g
E. Coli.:
Absent
Packaging&Delivery
Packaging Details
25kgs/Drum; 5kgs/Tin&10kgs/Carton
Port
Any main port of China

Property

CAS No.: 83881-52-1 Formula: C21H26Cl2N2O3 Molecular Weight: 425.34900

Description

A nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. Antihystaminic.

Basic Info

Chemical Name	Cetirizine Dihydrochloride
Synonyms	2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid,dihydrochloride;
CAS No.	83881-52-1
Molecular Formula	C21H26Cl2N2O3
Molecular Weight	425.34900
PSA	53.01000
LogP	3.82600

Properties

Density	1.237 g/cm3
Boiling Point	542.1ºC at 760 mmHg
Melting Point	110-115ºC
Flash Point	281.6ºC
Storage Condition	Desiccate at RT

Safety Info

Hazard Class	6.1(b)
Safety Statements	S26; S36
HS Code	2933599090
Packing Group	III
RIDADR	UN 3249
Risk Statements	R22
Hazard Codes	Xn

Synthesis Route

cetirizine→Cetirizine Dihydrochloride
2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethanol+Sodium chloroacetate→Cetirizine Dihydrochloride
Cetirizine Amide→Cetirizine Dihydrochloride

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	365 mg/kg	1.Behavioral-somnolence (general depressed activity) 2.Lungs, Thorax, or Respiration-respiratory depression 3.Nutritional and Gross Metabolic-body temperature decrease
Intraperitoneal	LDLo - Lowest published lethal dose	Rodent - mouse	138 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Oral	LD50 - Lethal dose, 50 percent kill	Mammal - dog	>320 mg/kg	1.Behavioral-somnolence (general depressed activity) 2.Gastrointestinal-hypermotility, diarrhea 3.Gastrointestinal-nausea or vomiting