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epalrestat

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Origin: China

Cas No: 82159-09-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
82159-09-9
Other Names:
Epalrestat
MF:
C15H13NO3S2
EINECS No.:
675-018-0
Place of Origin:
Shandong,China, Shandong China
Type:
Pancreatic hormone
Grade Standard:
Medicine Grade, Tech Grade
Usage:
Animal Pharmaceuticals
Brand Name:
Fousi, Fousi
Model Number:
FS 82159-09-9
Purity:
>99%, 99%min, 99%min
Form:
Powder
Color:
white
Package:
Aluminum Bag
Storage:
Cool Dried Storage
Assay:
99% Min
Sample:
Availiable
Shelf life:
2 Years Proper Storage
Packaging&Delivery
Packaging Details
Customers' Requirement
Port
QINGDAO ,SHANGHAI
Lead Time:
Quantity(Grams) 1 - 1 >1
Est. Time(days) 7 To be negotiated

Property

CAS No.: 82159-09-9 Formula: C15H13NO3S2 Molecular Weight: 319.39900

Description

Epalrestat is a carboxylic acid derivative and a noncompetitive and reversible aldose reductase inhibitor used for the treatment of diabetic neuropathy, which is one of the most common long-term complications in patients with diabetes mellitus. It reduces the accumulation of intracellular sorbitol which is believed to be the cause of diabetic neuropathy, retinopathy and nephropathy It is well tolerated, with the most commonly reported adverse effects being gastrointestinal issues such as nausea and vomiting, as well as increases in certain liver enzymes. Chemically, epalrestat is unusual in that it is a drug that contains a rhodanine group. Aldose reductase is the key enzyme in the polyol pathway whose enhanced activity is the basis of diabetic neuropathy. Aldose reductase inhibitors (ARI) target this enzyme. Out of the many ARIs developed, ranirestat and fidarestat are in the trial stage. Others have been discarded due to unacceptable adverse effects or weak efficacy. Epalrestat is the only ARI commercially available. It is easily absorbed into the neural tissue and inhibits the enzyme with minimum side effects.

Basic Info

Chemical Name	epalrestat
Synonyms	(Z,E)-5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid; Epalrestat; Kinedak; (Z,E)-5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxothiazolidine-3-acetic acid; 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid; 2-[(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid; Ono 2235;
CAS No.	82159-09-9
Molecular Formula	C15H13NO3S2
Molecular Weight	319.39900
PSA	115.00000
LogP	2.85660

Properties

Appearance & Physical State	Deep red acicular crystal
Density	1.43 g/cm3
Boiling Point	516.8ºC at 760 mmHg
Melting Point	210-217ºC
Flash Point	266.4ºC
Refractive Index	1.705
Storage Condition	Store in original container in a cool dark place.