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epolamine

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Origin: China

Cas No: 2955-88-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 2955-88-6 Formula: C6H13NO Molecular Weight: 115.17400

    Description

    Epolamine is a very useful synthetic intermediate. It is a reagent used to synthesize Diclofenac Epolamine which is a diclofenac salt with greater water solubility and better cutaneous absorption properties than other commonly used forms of the drug.

    Basic Info

    Chemical Name epolamine
    Synonyms

    2-Pyrrolidinoethanol;
    Epolamine;
    2-(Pyrrolidin-1-yl)ethanol;
    N-(2-Hydroxyethyl)pyrrolidine;
    1-(2-Hydroxyethyl)pyrrolidine;
    N-hydroxyethyl pyrrolidine;
    1-Pyrrolidineethanol;
    1-pyrrolinineethanol;
    Pyrrolidinoethanol;
    2-pyrrolidin-1-ylethanol;

    CAS No. 2955-88-6
    Molecular Formula C6H13NO
    Molecular Weight 115.17400
    PSA 23.47000
    LogP 0.01240

    Properties

    Appearance & Physical State Colorless liquid
    Density 0.985
    Boiling Point 79-81ºC (13 mmHg)
    Flash Point 56ºC
    Refractive Index 1.4713-1.4743
    Stability Stable under normal temperatures and pressures.
    Storage Condition Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area.
    Vapor Pressure 0.311mmHg at 25°C

    Safety Info

    RTECS UY1175000
    Hazard Class 3.2
    Safety Statements S23-S24/25
    HS Code 2933990090
    WGK Germany 3
    Packing Group III
    RIDADR UN 1993

    Synthesis Route

    pyrrolidine+Ethylene glycol→epolamine+1-(2-pyrrolidin-1-ylethyl)pyrrolidine
    pyrrolidine+2-chloroethanol→epolamine
    pyrrolidine+2-Bromoethanol→epolamine

    GC Analysis

    Column type Active phase Temperature (°C) Retention Index (I) Temperature Control Method
    Packed PEG-2000 152. 1552. isothermal
    Packed PEG-2000 179. 1564. isothermal
    Packed PEG-2000 200. 1590. isothermal

    Precursor

    2-Bromoethanol
    pyrrolidine
    2-chloroethanol
    prop-2-yn-1-ol

    Downstream Product

    2-pyrrolidin-1-ylethyl 4-propoxybenzoate
    4-(2-(Pyrrolidin-1-yl)ethoxy)aniline
    1-(2-Chloroethyl)-Pyrrolidine
    5-bromo-2-(2-pyrrolidin-1-ylethoxy)pyridine

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