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erythromycin B

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Origin: China

Cas No: 527-75-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 527-75-3 Formula: C37H67NO12 Molecular Weight: 717.92700

    Description

    Erythromycin B is a co-metabolite of Erythromycin A, an antibacterial agent.

    Basic Info

    Chemical Name erythromycin B
    Synonyms

    12-Deoxyerythromycin;
    Erythromycin B;
    (3R,4S,6R,7R,9R,11R,12S,13R,14R)-6-[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12-dihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione;

    CAS No. 527-75-3
    Molecular Formula C37H67NO12
    Molecular Weight 717.92700
    PSA 173.68000
    LogP 2.67070

    Properties

    Density 1.17 g/cm3
    Boiling Point 807.6ºC at 760mmHg
    Melting Point 168-170ºC (dec)
    Flash Point 442.2ºC
    Refractive Index 1.526

    Synthesis Route

    (2S,3R,4R,6R)-1,4-bis[(tert-butyldimethylsilyl)oxy]-3-[(4-methoxybenzyl)oxy]-2,4,6-trimethylnonan-7-one→erythromycin B
    (2S,3R,4R,6R)-1,4-bis[(tert-butyldimethylsilyl)oxy]-7,7-(ethylenedithio)-3-[(4-methoxybenzyl)oxy]-2,4,6-trimethylnonane→erythromycin B
    (9S)-3-O-(α-L-cladinosyl)-9-dihydro-5-O-(2-O-(methoxycarbonyl)-β-D-desosaminyl)erythronolide B→erythromycin B

    Precursor

    (2R,3R,4R,6R,7S,8S,9S,10S,11R)-11-[(benzyloxy)methoxy]-4-[(tert-butyldimethylsilyl)oxy]-3-[(4-methoxybenzyl)oxy]-2,4,6,8,10-pentamethyl-7,9-{[(R)-2,4,6-trimethylbenzylidene]dioxy}tridecanal
    (2S,3R,4R,6R)-1,4-bis[(tert-butyldimethylsilyl)oxy]-7,7-(ethylenedithio)-3-[(4-methoxybenzyl)oxy]-2,4,6-trimethylnonane
    (9S)-3-O-(α-L-cladinosyl)-9-dihydro-5-O-(2-O-(methoxycarbonyl)-β-D-desosaminyl)erythronolide B
    (2R,3S,4S,5R,6R,7R,9S,10S,11S,12S,13R)-6-[(tert-butyldimethylsilyl)-oxy]-13-hydroxy-3,5-{[(R)-4-methoxybenzylidene]dioxy}-2,4,6,8,10,12-hexamethyl-9,11-{[(R)-2,4,6-trimethylbenzylidene]dioxy}pentadecanoic acid

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