Irinotecan Hydrochloride Trihydrate

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Origin: China

Cas No: 136572-09-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 136572-09-3 Formula: C33H45ClN4O9 Molecular Weight: 677.18500

Description

Irinotecan Hydrochloride Trihydrate is a DNA topoisomerase inhibitor.

Basic Info

Chemical Name	Irinotecan Hydrochloride Trihydrate
Synonyms	(+)-(4S)-4,11-Diethyl-4-hydroxy-9-<(piperidinopiperidino)-carbonyloxy>-1H-pyrano<3',4':6,7>indolizino<1,2-b>quinoline-3,14-(4H,12H)-dione hydrochloride trihydrate; CPT-11 Trihydrate; Irinotecan hydrochloride trihydrate;
CAS No.	136572-09-3
Molecular Formula	C33H45ClN4O9
Molecular Weight	677.18500
PSA	141.89000
LogP	4.57600

Properties

Appearance & Physical State	Pale yellow to yellow crystalline powder
Boiling Point	873.4ºC at 760 mmHg
Melting Point	250-256ºC (dec.)
Flash Point	482ºC

Safety Info

HS Code	2934999090

Synthesis Route

Irinotecan hydrochloride→Irinotecan Hydrochloride Trihydrate

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	867 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Intravenous	LD50 - Lethal dose, 50 percent kill	Rodent - rat	83600 ug/kg	1.Details of toxic effects not reported other than lethal dose value
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	1045 mg/kg	1.Details of toxic effects not reported other than lethal dose value