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Levocetirizine

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Origin: China

Cas No: 130018-77-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 130018-77-8 Formula: C21H25ClN2O3 Molecular Weight: 388.88800

    Description

    Levocetirizine (as levocetirizine dihydrochloride) is a third-generation non-sedative antihistamine, developed from the second-generation antihistamine cetirizine. Chemically, levocetirizine is the active enantiomer of cetirizine. It is the R-enantiomer of the cetirizine racemate. Levocetirizine is an inverse agonist that decreases activity at histamine H1 receptors. This in turn prevents the release of other allergy chemicals and increased blood supply to the area, and provides relief from the typical symptoms of hay fever. It does not prevent the actual release of histamine from mast cells.
    The manufacturers claim it to be more effective with fewer side effects than the second-generation drugs; however, there have been no published studies supporting this assertion. A study part-funded by the manufacturer UCB concluded it may be more effective than some other second- and third-generation anti-histamines, but didn't compare it to cetirizine.

    Basic Info

    Chemical Name Levocetirizine
    Synonyms

    Levocarnitine;
    2-[2-[4-[(4-Chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid;
    Alerlisin;

    CAS No. 130018-77-8
    Molecular Formula C21H25ClN2O3
    Molecular Weight 388.88800
    PSA 53.01000
    LogP 3.02400

    Properties

    Appearance & Physical State white powder
    Density 1.237g/cm3
    Boiling Point 542.1ºC at 760mmHg
    Flash Point 281.6ºC
    Vapor Pressure 1.39E-12mmHg at 25°C

    Safety Info

    HS Code 2933599090

    Synthesis Route

    (R)-2-(2-{4-[(4-chlorophenyl)phenylmethyl]piperazin-1-yl}ethoxy)acetamide→Levocetirizine
    levocetirizine N-benzyl amide→Levocetirizine
    (+)-[2-[4-[(4-chlorophenyl)-phenyl methyl]-1-piperazinyl]]ethanol+Sodium chloroacetate→Levocetirizine

    Precursor

    Sodium chloroacetate
    (R)-2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-1-(S)-[N-(1-phenyIethyl)]acetamide
    (R)-2-(2-{4-[(4-chlorophenyl)phenylmethyl]piperazin-1-yl}ethoxy)acetamide
    levocetirizine N-benzyl amide

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