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Meprednisone

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Origin: China

Cas No: 83-43-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
83-43-2
Other Names:
Methylprednisolone
MF:
C22H30O5
EINECS No.:
201-476-4
Place of Origin:
Shanghai, China
Type:
Anesthetic Agents, Anti-Allergic Agents, Antibiotic and Antimicrobial Agents, Antidote, Auxiliaries and Other Medicinal Chemicals, Blood System Agents, Cardiovascular Agents, Disinfectant and Preservatives, Endocrine System Agents, Immune Function Agents
Grade Standard:
Cosmetic Grade, Feed Grade, Food Grade, Medicine Grade, Tech Grade
Brand Name:
TERPPON
Model Number:
922
Purity:
99%
color:
white
Packaging&Delivery
Packaging Details
in 25kg drum
Port
SHANGHAI

Property

CAS No.: 83-43-2 Formula: C22H30O5 Molecular Weight: 374.47100

Description

Methylprednisolone is a synthetic glucocorticoid or corticosteroid drug. It is marketed in the USA and Canada under the brand names Medrol and Solu-Medrol. It is also available as a generic drug.
It is a variant of prednisolone, methylated at carbon 6 of the B ring.
It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.

Basic Info

Chemical Name	Meprednisone
Synonyms	(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one; 6alpha-methylprednisolone; Methylprednisolone; 6α-methylprednisolone;
CAS No.	83-43-2
Molecular Formula	C22H30O5
Molecular Weight	374.47100
PSA	94.83000
LogP	1.80360

Properties

Appearance & Physical State	white to off-white crystalline powder
Density	1.28
Boiling Point	571.8ºC at 760 mmHg
Melting Point	228-237ºC (dec.)
Refractive Index	82 ° (C=1, Dioxane)
Storage Condition	0-6ºC

Safety Info

RTECS	TU4146000
Safety Statements	S22-S36
WGK Germany	2
Risk Statements	R36/37/38
Hazard Codes	Xi

Synthesis Route

17α-acetoxy-11β,21-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione→Meprednisone+Methylprednisolone acetate
(20Ξ)-11β-hydroxy-6α-methyl-17,20,20,21-bis-methylenedioxy-pregna-1,4-dien-3-one→Meprednisone
cortisone→Meprednisone

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Parenteral	TDLo - Lowest published toxic dose	Human - woman	2400 ug/kg	1.Cardiac-change in rate 2.Lungs, Thorax, or Respiration-respiratory depression 3.Nutritional and Gross Metabolic-body temperature increase
Intravenous	TDLo - Lowest published toxic dose	Human - woman	60 mg/kg/3D-I	1.Cardiac-pulse rate increase, without fall in BP 2.Vascular-BP lowering not characterized in autonomic section 3.Nutritional and Gross Metabolic-body temperature increase
Intravenous	TDLo - Lowest published toxic dose	Human - woman	20 mg/kg/45M-C	1.Cardiac-arrhythmias (including changes in conduction)

Precursor

11β,21-dihydroxy-6α-methyl-pregna-4,17(20)c-dien-3-one
(20Ξ)-11β-hydroxy-6α-methyl-17,20,20,21-bis-methylenedioxy-pregna-1,4-dien-3-one
21-acetoxy-11β-hydroxy-6α-methyl-pregna-1,4,17(20)c-trien-3-one

Downstream Product

6α-Methyl Hydrocortisone
Pregna-1,4-diene-3,20-dione, 21-fluoro-11.β.,17-dihydroxy-6.α.-methyl-
Methylprednisolone acetate
1-[4-(2-methylbutan-2-yl)phenoxy]butan-2-yl prop-2-ynyl sulfite

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