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(R)-2-((tert-Butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)propanoic acid

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Origin: China

Cas No: 486460-09-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 486460-09-7 Formula: C14H16F3NO4 Molecular Weight: 319.27600

Basic Info

Chemical Name	(R)-2-((tert-Butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)propanoic acid
Synonyms	BOC-D-2,4,5-TRIFLUOROPHE;
CAS No.	486460-09-7
Molecular Formula	C14H16F3NO4
Molecular Weight	319.27600
PSA	75.63000
LogP	3.01520

Safety Info

HS Code	2924299090

Synthesis Route

METHYL (2R)-2-[(TERT-BUTOXYCARBONYL)AMINO]-3-(2,4,5-TRIFLUOROPHENYL)PROPANOATE→(R)-2-((tert-Butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)propanoic acid
tert-butoxycarbonyl anhydride→(R)-2-((tert-Butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)propanoic acid
2,4,5-Trifluorobenzyl bromide→(R)-2-((tert-Butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)propanoic acid

Precursor

tert-butoxycarbonyl anhydride
METHYL (2R)-2-[(TERT-BUTOXYCARBONYL)AMINO]-3-(2,4,5-TRIFLUOROPHENYL)PROPANOATE
(2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2',4',5'-trifluorobenzyl)-pyrazine
2,4,5-Trifluorobenzyl bromide

Downstream Product

sitagliptin
Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid

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