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Tenofovir diethyl ester

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Origin: China

Cas No: 180587-75-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 180587-75-1 Formula: C13H22N5O4P Molecular Weight: 343.31900

Description

A acyclic phosphonate nucleotide.

Basic Info

Chemical Name	Tenofovir diethyl ester
Synonyms	9-[(2S)-2-(diethoxyphosphorylmethoxy)propyl]purin-6-amine; Phosphonic acid, P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, diethyl ester;
CAS No.	180587-75-1
Molecular Formula	C13H22N5O4P
Molecular Weight	343.31900
PSA	124.19000
LogP	2.61840

Properties

Density	1.423g/cm3
Boiling Point	532.44ºC at 760 mmHg
Melting Point	107-109ºC
Flash Point	275.81ºC
Refractive Index	1.611
Vapor Pressure	0mmHg at 25°C

Synthesis Route

(S)-1-(6-Amino-9H-purin-9-yl)propan-2-ol+diethoxyphosphorylmethyl 4-methylbenzenesulfonate→Tenofovir diethyl ester
diethoxyphosphorylmethyl 4-methylbenzenesulfonate+(R)-(+)-9-(2-Hydroxypropyl)Adenine→Tenofovir diethyl ester
(2R)-1-(6-chloropurin-9-yl)propan-2-ol→Tenofovir diethyl ester

Precursor

(S)-1-(6-Amino-9H-purin-9-yl)propan-2-ol
diethoxyphosphorylmethyl 4-methylbenzenesulfonate
(2R)-1-(6-chloropurin-9-yl)propan-2-ol
(R)-(+)-9-(2-Hydroxypropyl)Adenine

Downstream Product

tenofovir (anhydrous)
({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphinic acid
tenofovir disoproxil fumarate

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