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Trientine dihydrochloride

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Origin: China

Cas No: 38260-01-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 38260-01-4 Formula: C6H20Cl2N4 Molecular Weight: 219.15600

Description

Triethylenetetramine Hydrochloride is a selective CuII-chelator; crosslinking agent. Triethylenetetramine is undergoing trials for the treatment of heart failure in patients with diabetes.

Basic Info

Chemical Name	Trientine dihydrochloride
Synonyms	N,N'-bis(2-aminoethyl)ethane-1,2-diamine dihydrochloride; EINECS 253-854-3; MK-0681; Triethylenetetramine dihydrochloride; Trien dihydrochloride; N,N'-bis(2-aminoethyl)-1,2-ethanediamine dihydrochloride; N'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine,dihydrochloride; Syprine; Triethylenetetraamine dihydrochloride; Trientine hydrochloride (USP);
CAS No.	38260-01-4
Molecular Formula	C6H20Cl2N4
Molecular Weight	219.15600
PSA	76.10000
LogP	1.86940

Properties

Appearance & Physical State	white crystalline powder
Density	0.958 g/cm3
Boiling Point	266.5ºC at 760 mmHg
Melting Point	120-125ºC (dec.)
Flash Point	143.3ºC
Storage Condition	0-6ºC

Safety Info

Safety Statements	S26
HS Code	2921290000
Risk Statements	R36/37/38
Hazard Codes	Xi
Caution Statement	P261; P305 + P351 + P338
Signal Word	Warning
Hazard Declaration	H315; H319; H335
Symbol	GHS07

Synthesis Route

Triethylenetetramine tetrahydrochloride→Trientine dihydrochloride
1,3-bis-(2-benzylidenamino-ethyl)-2-phenyl-imidazolidine→Trientine dihydrochloride

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	2285 mg/kg	1.Lungs, Thorax, or Respiration-cyanosis 2.Lungs, Thorax, or Respiration-other changes 3.Gastrointestinal-ulceration or bleeding from stomach
Oral	TDLo - Lowest published toxic dose	Rodent - mouse	67500 mg/kg/90D-I	1.Lungs, Thorax, or Respiration-other changes 2.Liver-fatty liver degeneration 3.Blood-changes in spleen
Oral	TDLo - Lowest published toxic dose	Rodent - mouse	1140 uL/kg,female 1-19 day(s) after conception	1.Reproductive-Effects on Embryo or Fetus-fetotoxicity (except death, e.g., stunted fetus) 2.Reproductive-Effects on Embryo or Fetus-other effects to embryo