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Trospium Chloride

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Origin: China

Cas No: 10405-02-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
10405-02-4
Other Names:
Trospium chloride
MF:
C25H30ClNO3
EINECS No.:
233-875-4
Place of Origin:
Shanghai, China
Type:
Anesthetic Agents, Anti-Allergic Agents, Antibiotic and Antimicrobial Agents, Antidote, Antipyretic Analgesics and NSAIDs, Auxiliaries and Other Medicinal Chemicals, Disinfectant and Preservatives
Grade Standard:
Cosmetic Grade, Feed Grade, Food Grade, Medicine Grade, Tech Grade
Brand Name:
Terppon
Model Number:
133
Purity:
99%
color:
white
Packaging&Delivery
Packaging Details
in 25kg net per drum
Port
shanghai
Lead Time:
1 week
Property
CAS No.: 10405-02-4 Formula: C25H30ClNO3 Molecular Weight: 427.96400

Description
Trospium chloride (INN) is used to treat overactive bladder.
It has side effects typical of drugs like it, namely dry mouth, stomach upset, and constipation; these side effects cause problems with people taking their medicine as directed. However it doesn't cause central nervous system side effects like other drugs of its class. It is pregnancy category C and is excreted somewhat in breast milk.
Chemically it is a quaternary ammonium cation which causes it to stay in periphery rather than crossing the blood-brain barrier. It works by causing the smooth muscle in the bladder to relax.
It was invented in the late 1960s in Germany and was first approved in Europe in 1999. It was first approved in the US in 2004, and an extended release version with once a day dosing was brought to market in 2007. It became generic in Europe in 2009 and in the US the first extended-release generic was approved in 2012.

Basic Info

Chemical Name Trospium Chloride

Synonyms
Trospium chloride;

CAS No. 10405-02-4

Molecular Formula C25H30ClNO3

Molecular Weight 427.96400

PSA 46.53000

LogP 0.73250

Properties

Appearance & Physical State white to off-white powder

Melting Point 266-268ºC

Synthesis Route
(1S,5R)-spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]-3-ol,chloride+2-hydroxy-1-imidazol-1-yl-2,2-diphenylethanone→Trospium Chloride

Precursor
2-hydroxy-1-imidazol-1-yl-2,2-diphenylethanone
(1S,5R)-spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]-3-ol,chloride