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1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil

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Origin: China

Cas No: 69123-98-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
69123-98-4
Other Names:
MBMB
MF:
C9H10FIN2O5
EINECS No.:
N/A
Place of Origin:
China, CN
Type:
Agrochemical Intermediates, Pharmaceutical Intermediates, Syntheses Material Intermediates
Purity:
99min%
Brand Name:
Milliflux
Model Number:
Nucleotide
Application:
Pharmaceutical Raw Intermediates
Appearance:
Colourless crystals
Packing:
25kg/drum or 20kg/bag
Assay:
99.0 %min
Storage:
Room Temperature
Shelf life:
Proper Storage
Grade:
EP,USP,CP,JP
Brand:
Milliflux
Website:
www.milliflux.com
Origin:
China
Packaging&Delivery
Packaging Details
Customer's request
Port
Any main port in china
Lead Time:
Quantity(Kilograms) 1 - 2 >2
Est. Time(days) 15 To be negotiated

Property

CAS No.: 69123-98-4 Formula: C9H10FIN2O5 Molecular Weight: 372.08900

Description

Fialuridine, or 1-(2-deoxy-2-fluoro-1-D-arabinofuranosyl)-5-iodouracil (FIAU), is a nucleoside analogue that was investigated as a potential therapy for hepatitis B virus infection. In a 1993 clinical study at the NIH, unexpected toxicity led to the death of 5 out of 15 patients from liver failure associated with lactic acidosis; two further participants required liver transplantation. This toxicity was unusual in that it was not predicted by animal studies. It is suspected that the drug's toxicity was due to its damaging mitochondria.

Basic Info

Chemical Name	1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil
Synonyms	1-[(2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione;
CAS No.	69123-98-4
Molecular Formula	C9H10FIN2O5
Molecular Weight	372.08900
PSA	104.55000
LogP	-1.27010

Properties

Appearance & Physical State	Colourless crystals
Density	2.18 g/cm3
Melting Point	216-217ºC
Refractive Index	1.685

Safety Info

HS Code	2934999090

Synthesis Route

[(2R,4R,5R)-3-benzoyloxy-4-fluoro-5-(5-iodo-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl benzoate→1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil
1-(O3-acetyl-O5-benzoyl-2-fluoro-β-D-2-deoxy-arabinofuranosyl)-1H-pyrimidine-2,4-dione→1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil
1-(3',5'-di-O-benzoyl-2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)-5-bromouracil→1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil

Precursor

[(2R,3R,4S,5R)-3-benzoyloxy-5-bromo-4-fluorooxolan-2-yl]methyl benzoate
[(2R,4R,5R)-3-benzoyloxy-4-fluoro-5-(5-iodo-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl benzoate
1-(3',5'-di-O-benzoyl-2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)-5-bromouracil
1,3,5-Tri-O-Benzoyl-2-Deoxy-2-Fluoro -α-D-Arabinose

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