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podophyllotoxin

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Origin: China

Cas No: 518-28-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details

Type:: Podophyllotoxin

Form:: Powder

Part:: Leaf

Extraction Type:: Solvent Extraction

Packaging:: DRUM, Vacuum Packed

Place of Origin:: Shaanxi, China

Grade:: Pharmaceutical Grade

Brand Name:: Yangge

Model Number:: Podophyllotoxin

Product Name:: Podophyllotoxin

Appearance:: White fine Powder

CAS NO.:: 518-28-5

Active ingrident::: Podophyllotoxin 98%

Application:: health care products/food/pharmeceutical

Specification:: 98%

Test Method:: HPLC

Molecular Formula:: C22H22O8

Molecular Weight:: 414.405

Melting point::: 597.9±50.0 °C at 760 mmHg

Packaging&Delivery

Packaging Details: 1.25kg/drum (25kg net weight, 28kg gross weight;
Packed in a cardboard-drum with two
plastic-bags inside;
Drum Size: 510mm high, 360mm diameter)
2. 1kg/bag (1kg net weight, 1.2kg gross weight, packed in an aluminum foil bag;
Outer: paper carton; Inner: double-layer PE)

Port: SHANGHAI/QINGAO/NINGBO/TIANJIN/BEIJING

Lead Time:

Quantity(Kilograms)	1 - 50	>50
Est. Time(days)	7	To be negotiated

Products Description

Product name	Podophyllotoxin
Appearance:	White Powder
CAS No	518-28-5
Molecular Formula	C22H22O8
Active ingredients	Podophyllotoxin
Specification	podophyllotoxin 98% Podophyllum Resin 50%
Use Part	Root/leaf
Appearance	White Powder
Mesh size	80 Mesh
Test Method	HPLC

Property

CAS No.: 518-28-5 Formula: C22H22O8 Molecular Weight: 414.40500

Description

Podophyllotoxin (abbreviated as PPT), otherwise known as podofilox, is a non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum species. Under the trade names Condylox, a gel, and Wartec, a solution or cream, it is used on the skin as a topical treatment of external genital warts, caused by some types of the human papillomavirus (HPV), and other warts. PPT and its synthetic derivatives display a wide selection in medical applications such as purgative, vesicant, antirheumatic, antiviral, and antitumor agents. These derivatives include etoposide and teniposide. Their anticancer activity has been heavily under study and used in various chemotherapies, including lung cancer, lymphomas, and genital tumors.
Historically, podophyllin, a resin extracted from Podophyllum and Sinopodophyllum species, was also used.
It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.

Basic Info

Chemical Name	podophyllotoxin
Synonyms	Podophyllotoxin; Furo[3‘,4‘:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, [5R-(5-,5aα,8a-,9-)]-; (5R,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one;
CAS No.	518-28-5
Molecular Formula	C22H22O8
Molecular Weight	414.40500
PSA	92.68000
LogP	2.40920

Properties

Appearance & Physical State	Light yellow-beige powder.
Density	1.37g/cm3
Boiling Point	597.9ºC at 760 mmHg
Melting Point	178-184ºC
Flash Point	210.2ºC
Stability	Stable under normal temperatures and pressures.
Storage Condition	2-8ºC

Safety Info

RTECS	LV2500000
Hazard Class	6.1(a)
Safety Statements	S45
HS Code	2942000000
WGK Germany	3
Packing Group	II
RIDADR	UN 3462 6.1/PG 2
Risk Statements	R23/25
Hazard Codes	T
Signal Word	Danger
Hazard Declaration	H301; H310; H315; H319; H335
Symbol	GHS06
Caution Statement	P261; P280; P302 + P350; P305 + P351 + P338; P310

Synthesis Route

PPPone→podophyllotoxin
(5R,6R,7R,8R)-methyl 8-hydroxy-7-(hydroxymethyl)-5-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydronaphtho[2,3-d][1,3]dioxole-6-carboxylate→podophyllotoxin
(-)-4-O-(tert-butyldimethylsilyl)podophyllotoxin→podophyllotoxin

Precursor

(5R,6R,7R,8R)-methyl 8-hydroxy-7-(hydroxymethyl)-5-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydronaphtho[2,3-d][1,3]dioxole-6-carboxylate
(-)-4-O-(tert-butyldimethylsilyl)podophyllotoxin
PPPone
(1R,2R,3R,4R)-4-O-(2'-trimethylsilylethoxy)methylpodophyllotoxin

Downstream Product

picropodophyllotoxin
(5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
4'-demethylpodophyllotoxin
(5R)-5-(3,4,5-trimethoxyphenyl)-8,9-dihydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-6-one

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