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1,3-bis(2-chloroethyl)urea

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Origin: China

Cas No: 2214-72-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 2214-72-4 Formula: C5H10Cl2N2O Molecular Weight: 185.05200

Description

1,3-Bis(2-chloroethyl)urea is an impurity in the synthesis of Carmustine, an alkylating and carbamoylating nitrosourea compound. It interacts with DNA, RNA and proteins causing DNA interstrand cross linking which is cytotoxic and leads to apoptotic cell death.

Basic Info

Chemical Name	1,3-bis(2-chloroethyl)urea
Synonyms	Carmustine impurity A; PARENT UREA;
CAS No.	2214-72-4
Molecular Formula	C5H10Cl2N2O
Molecular Weight	185.05200
PSA	41.13000
LogP	1.54500

Properties

Density	1.245g/cm3
Boiling Point	358.2ºC at 760mmHg
Flash Point	170.4ºC
Refractive Index	1.478
Vapor Pressure	2.59E-05mmHg at 25°C

Safety Info

HS Code	2924199090

Synthesis Route

carmustine→1,3-bis(2-chloroethyl)urea+N-(2-chloroethyl)-4,5-dihydro-2-oxazolamine
2-Chloroethyl isocyanate→1,3-bis(2-chloroethyl)urea
2-Chloroethyl isocyanate+2-Chloroethanamine→1,3-bis(2-chloroethyl)urea

Precursor

2-Chloroethyl isocyanate
N,N'-Disuccinimidyl carbonate
2-Chloroethylamine hydrochloride
2-Chloroethanamine

Downstream Product

1,3-bis(2-iodoethyl)urea
carmustine
N-(2-chloroethyl)-4,5-dihydro-1,3-oxazol-2-amine,hydrochloride
N-(2-chloroethyl)-3-nitroso-1,3-oxazolidin-2-imine

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