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2,2,6,6-Tetramethylpiperidine

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Origin: China

Cas No: 768-66-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
768-66-1
Other Names:
TEMP
MF:
C9H19N
EINECS No.:
212-199-3
Place of Origin:
Jiangsu, China
Type:
Pharmaceutical Intermediates, Syntheses Material Intermediates
Purity:
99%
Brand Name:
KPRX
Model Number:
CAS 768-66-1
Application:
Pharmaceutical Intermediates, syntheses of HMP-Y1
Appearance:
Clear colorless to yellow liquid, Clear colorless to yellow liquid
Product name:
Intermediate High Purity 2,2,6,6-Tetramethylpiperidine 768-66-1
Name:
2,2,6,6-Tetramethylpiperidine
Keyword:
syntheses of Hibarimicinone and HMP-P1
Description:
API intermediates
Packaging&Delivery
Packaging Details
20kg/drum
Pallet can be avialable for bulk order.
Port
shanghai or ningbo
Lead Time:
Quantity(Kilograms) 1 - 100 >100
Est. Time(days) 3 To be negotiated

Property

CAS No.: 768-66-1 Formula: C9H19N Molecular Weight: 141.25400

Description

2,2,6,6-Tetramethylpiperidine or TMP or HTMP is an organic compound of the amine class. In appearance, it is a colorless liquid and has a "fishy", amine-like odor. This amine is used in chemistry as a hindered base (hindered amine) because it can dissolve in organic solvents unlike inorganic bases such as potassium hydroxide.
There are many ways to synthesise TMP. One method starts with a conjugate addition reaction of ammonia to phorone. The intermediate triacetone amine is then reduced in a Wolff-Kishner reaction.
TMP is the starting material for an even stronger base lithium tetramethylpiperidide and the radical species TEMPO. Another non-nucleophilic base is N,N-diisopropylethylamine.
Tefenperate is made from 2,2,6,6-Tetramethylpiperidine precursor.

Basic Info

Chemical Name	2,2,6,6-Tetramethylpiperidine
Synonyms	2,2,6,6-Me4piperidine; PIPERIDINE,2,2,6,6-TETRAMETHYL; Piperidine, 2,2,6,6-tetramethyl-; EINECS 212-199-3; 2,2,6,6-Tetramethylpeperidine; 2,2,6,6-TETRAMETHYL-1-PIPERIDINYLOXY; 2,2,6,6-tetramethyl-piperidine; Norpempidine;
CAS No.	768-66-1
Molecular Formula	C9H19N
Molecular Weight	141.25400
PSA	12.03000
LogP	2.64590

Properties

Appearance & Physical State	clear colorless to light yellow-green liquid
Density	0.837
Boiling Point	152ºC
Melting Point	-59ºC
Flash Point	24ºC
Refractive Index	1.443-1.446
Water Solubility	MISCIBLE
Stability	Stable at room temperature in closed containers under normal storage and handling conditions.
Storage Condition	Flammables area

Safety Info

RTECS	TN4220000
Hazard Class	3
Safety Statements	S16-S26-S37/39
HS Code	29333999
Packing Group	III
WGK Germany	2
RIDADR	UN 1992
Risk Statements	R10; R22; R36/37/38
Hazard Codes	Xn

Synthesis Route

TEMPO+Ethanethiol→2,2,6,6-Tetramethylpiperidine+Diethyl disulfide
2,4-Di-tert-butylphenol+2,2,6,6-tetramethylpiperidin-1-ium 1-oxide,chloride→2,2,6,6-Tetramethylpiperidine+3,5-ditert-butylcyclohexa-3,5-diene-1,2-dione
Triacetonamine→2,2,6,6-Tetramethylpiperidine+2,2,6,6-tetramethylpiperidin-4-ol

GC Analysis

Column type	Active phase	Temperature (°C)	Retention Index (I)	Temperature Control Method
Capillary	Methyl Silicone	-	947.	custom temperature program

Precursor

TEMPO
1,2,2,6,6-PENTAMETHYLPIPERIDINE
Benzylamine
Triacetonamine

Downstream Product

6-Bromo-2,3-difluorobenzaldehyde
Lithium 2,2,6,6-tetramethylpiperidide
3,5-dichloropyrazine-2-carboxylic acid
(4-methoxyphenyl)-(2,2,6,6-tetramethylpiperidin-1-yl)methanone

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