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2-(2-methoxyphenyl)-4,4-dimethyl-5H-1,3-oxazole

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Origin: China

Cas No: 57598-33-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 57598-33-1 Formula: C12H15NO2 Molecular Weight: 205.25300

Description

2-(2-Methoxyphenyl)-4,4-dimethyl-4,5-dihydrooxazole is an intermediate in the synthesis of Candesartan-d4, the labeled analogue of Candesartan, an angiotensin II type-1 receptor antagonist. Used in treatment of congestive heart failure. Antihypertensive.

Basic Info

Chemical Name	2-(2-methoxyphenyl)-4,4-dimethyl-5H-1,3-oxazole
Synonyms	2-(2-methoxyphenyl)-4,4-dimethyl-4,5-dihydrooxazole; 2-(2-Methoxyphenyl)-4,4-dimethyl-2-oxazoline; 1-<4,4-dimethyl-(2,5-oxazolinyl)>-2-methoxybenzene; 1-methoxy-2-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)benzene; 4,5-dihydro-2-(2-methoxyphenyl)-4,4-dimethyloxazole; 1-(4,4-dimethyl(1,3-oxazolin-2-yl))-2-methoxybenzene; 4,4-dimethyl-2-(2-methoxyphenyl)oxazoline;
CAS No.	57598-33-1
Molecular Formula	C12H15NO2
Molecular Weight	205.25300
PSA	30.82000
LogP	1.68620

Properties

Appearance & Physical State	White to cream/pink solid
Density	1.08 g/cm3
Boiling Point	311.5ºC at 760 mmHg
Melting Point	71-74ºC
Flash Point	116.6ºC
Refractive Index	1.531

Safety Info

Safety Statements	S22-S24/25
HS Code	2934999090
Risk Statements	R36/37/38
Hazard Codes	Xi

Synthesis Route

N-(1-hydroxy-2-methylpropan-2-yl)-2-methoxybenzamide→2-(2-methoxyphenyl)-4,4-dimethyl-5H-1,3-oxazole
O-methylsalicylic acid→2-(2-methoxyphenyl)-4,4-dimethyl-5H-1,3-oxazole
2-methoxybenzoyl chloride→2-(2-methoxyphenyl)-4,4-dimethyl-5H-1,3-oxazole

Precursor

2-Methoxybenzonitrile
2-Amino-2-methyl-1-propanol
2-methoxybenzoyl chloride
O-methylsalicylic acid

Downstream Product

(2-propan-2-ylphenyl)methanol
2-[2-(trifluoromethyl)phenyl]benzoic acid
2-(2,4-dimethylphenyl)benzoic acid
O-methylsalicylic acid

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