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[2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate

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Origin: China

Cas No: 55981-09-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
55981-09-4
Other Names:
Nitazoxanide
MF:
C12H9N3O5S
EINECS No.:
/
Place of Origin:
Fujian, China
Type:
Antibiotic and Antimicrobial Agents
Grade Standard:
Medicine Grade
Usage:
Animal Pharmaceuticals
Brand Name:
SINOWAY
Model Number:
SINOWAY
Purity:
98%
Product Name:
Nitazoxanide
Packaging&Delivery
Packaging Details
25kg/drum, or as your requirement
Port
Shanghai/jiangsu/Beijing/Xiamen
Lead Time:
Quantity(Kilograms) 1 - 100 >100
Est. Time(days) 7 To be negotiated

Property

CAS No.: 55981-09-4 Formula: C12H9N3O5S Molecular Weight: 307.28200

Description

Nitazoxanide is a broad-spectrum antiparasitic and broad-spectrum antiviral drug that is used in medicine for the treatment of various helminthic, protozoal, and viral infections. It is indicated for the treatment of infection by Cryptosporidium parvum and Giardia lamblia in immunocompetent individuals and has been repurposed for the treatment of influenza. Nitazoxanide has also been shown to have in vitro antiparasitic activity and clinical treatment efficacy for infections caused by other protozoa and helminths; emerging evidence suggests that it possesses efficacy in treating a number of viral infections as well.
Chemically, nitazoxanide is the prototype member of the thiazolides, a class of drugs which are synthetic nitrothiazolyl-salicylamide derivatives with antiparasitic and antiviral activity. Tizoxanide, an active metabolite of nitazoxanide in humans, is also an antiparasitic drug of the thiazolide class.

Basic Info

Chemical Name	[2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate
Synonyms	Cryptaz; Heliton; Nitazoxanide; Nitazoxanidum; Alinia; Daxon; Nitazoxamide; Nitazoxanida; [14C]-Nitazoxanide; Colufase;
CAS No.	55981-09-4
Molecular Formula	C12H9N3O5S
Molecular Weight	307.28200
PSA	142.35000
LogP	2.82510

Properties

Appearance & Physical State	Yellowish to white crystalline powder
Density	1.532 g/cm3
Melting Point	202ºC
Storage Condition	-20ºC Freezer

Safety Info

HS Code	2942000000
Caution Statement	P261; P305 + P351 + P338
Signal Word	Warning
Hazard Declaration	H302; H315; H319; H335
Symbol	GHS07

Synthesis Route

2-Amino-5-nitrothiazole+O-Acetylsalicylryl chloride→[2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	>10 gm/kg	1.Behavioral-somnolence (general depressed activity) 2.Behavioral-muscle weakness
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	1350 mg/kg	1.Behavioral-somnolence (general depressed activity) 2.Behavioral-muscle weakness
Oral	LD - Lethal dose	Mammal - dog	>10 gm/kg	1.Autonomic Nervous System-smooth muscle relaxant (mechanism undefined, spasmolytic)