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2'-O-methyluridine

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Origin: China

Cas No: 2140-76-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 2140-76-3 Formula: C10H14N2O6 Molecular Weight: 258.22800

Description

Uridine analog. Used for preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication.

Basic Info

Chemical Name	2'-O-methyluridine
Synonyms	1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]pyrimidine-2,4-dione; 2'-O-Methyluridine; 2''-O-METHYLURIDINE CRYSTALLINE; 2'-O-methyl-uridine; 1-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]pyrimidine-2,4-quinone; 1-[(2S,3S,4R,5S)-4-hydroxy-5-(hydroxyMethyl)-3-Methoxyoxolan-2-yl]-1,2,3,4-tetrahydropyriMidine-2,4-dione; 1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxyMethyl)-3-Methoxytetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione; 2’-OMeUridine; 2-O-Methyluridine; 2'-O-GALLOYLHYPERIN,CERTIFIED REFERENCE MATERIAL; 2'-OMe uridine; 2'-O-METHYLURIDINE (CHIRAL);
CAS No.	2140-76-3
Molecular Formula	C10H14N2O6
Molecular Weight	258.22800
PSA	113.78000
LogP	-2.19780

Properties

Appearance & Physical State	White solid
Density	1.53 g/cm3
Melting Point	154-156ºC
Refractive Index	1.611
Storage Condition	Store at 0ºC

Safety Info

Safety Statements	S24/25
HS Code	2934999090
WGK Germany	3
Risk Statements	R26/27/28
Hazard Codes	T+

Synthesis Route

→2'-O-methyluridine
1'-(3',5'-O-benzyl-2'-O-methyl-β-D-ribofuranosyl)uracil→2'-O-methyluridine
3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disilyl)-2'-O-methyluridine→2'-O-methyluridine

Precursor

1'-(3',5'-O-benzyl-2'-O-methyl-β-D-ribofuranosyl)uracil
trimethyl borate
1-((2R,4S,5R)-3,4-anhydro-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-4(1H)-one
3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disilyl)-2'-O-methyluridine

Downstream Product

2'-(O-METHYL)-5-IODOURIDINE
1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione

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