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Home > All categories> Biochemicals and Pharmaceutical Chemicals> Active Pharmaceutical Ingredients (APIs)> Malignant disease> 4'-epidoxorubicin
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4'-epidoxorubicin

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Origin: China

Cas No: 56420-45-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 56420-45-2 Formula: C27H29NO11 Molecular Weight: 543.51900

    Description

    Epirubicin is an anthracycline drug used for chemotherapy. It can be used in combination with other medications to treat breast cancer in patients who have had surgery to remove the tumor. It is marketed by Pfizer under the trade name Ellence in the US and Pharmorubicin or Epirubicin Ebewe elsewhere.
    Similarly to other anthracyclines, epirubicin acts by intercalating DNA strands. Intercalation results in complex formation which inhibits DNA and RNA synthesis. It also triggers DNA cleavage by topoisomerase II, resulting in mechanisms that lead to cell death. Binding to cell membranes and plasma proteins may be involved in the compound's cytotoxic effects. Epirubicin also generates free radicals that cause cell and DNA damage.
    Epirubicin is favoured over doxorubicin, the most popular anthracycline, in some chemotherapy regimens as it appears to cause fewer side-effects. Epirubicin has a different spatial orientation of the hydroxyl group at the 4' carbon of the sugar - it has the opposite chirality - which may account for its faster elimination and reduced toxicity. Epirubicin is primarily used against breast and ovarian cancer, gastric cancer, lung cancer and lymphomas.

    Basic Info

    Chemical Name 4'-epidoxorubicin
    Synonyms

    WP 697;
    imi28;
    Pidorubicin;
    Adriblastin;
    epi-dx;
    farmorubicin;
    4'-Epi-DX;
    Epirubicin;
    Epiadriamycin;
    Farmarubicin;
    4'-epiadriamycin;

    CAS No. 56420-45-2
    Molecular Formula C27H29NO11
    Molecular Weight 543.51900
    PSA 206.07000
    LogP 0.70160

    Properties

    Density 1.61 g/cm3
    Boiling Point 810.3ºC at 760 mmHg
    Refractive Index 1.71

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Intravenous LD50 - Lethal dose, 50 percent kill Rodent - rat 14270 ug/kg 1.Nutritional and Gross Metabolic-weight loss or decreased weight gain
    Intravenous LD50 - Lethal dose, 50 percent kill Rodent - mouse 16070 ug/kg 1.Nutritional and Gross Metabolic-weight loss or decreased weight gain
    Unreported LD50 - Lethal dose, 50 percent kill Rodent - mouse 29300 ug/kg 1.Details of toxic effects not reported other than lethal dose value

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