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Irinotecan

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Origin: China

Cas No: 97682-44-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 97682-44-5 Formula: C33H38N4O6 Molecular Weight: 586.67800

Description

Irinotecan (Camptosar, Campto) is a drug used for the treatment of cancer.
Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. In chemical terms, it is a semisynthetic analogue of the natural alkaloid camptothecin.
Its main use is in colon cancer, in particular, in combination with other chemotherapy agents. This includes the regimen FOLFIRI, which consists of infusional 5-fluorouracil, leucovorin, and irinotecan.
Irinotecan received accelerated approval by the U.S. Food and Drug Administration (FDA) in 1996 and full approval in 1998. During development, it was known as CPT-11.
It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.

Basic Info

Chemical Name	Irinotecan
Synonyms	7-ethoxyxanthone-3-carboxylic acid; 9H-Xanthene-3-carboxylic acid,7-ethoxy-9-oxo;
CAS No.	97682-44-5
Molecular Formula	C33H38N4O6
Molecular Weight	586.67800
PSA	114.20000
LogP	3.96690

Safety Info

Risk Statements	R22

Synthesis Route

[1,4'-bipiperidine]-1'-carbonyl chloride+7-Ethyl-10-hydroxycamptothecin→Irinotecan
phosgene+7-Ethyl-10-hydroxycamptothecin→Irinotecan
1,4'-bipiperidine→Irinotecan

Precursor

1,4'-bipiperidine
7-Ethyl-10-hydroxycamptothecin
phosgene
bis(trichloromethyl) carbonate

Downstream Product

1,4'-bipiperidine
7-Ethyl-10-hydroxycamptothecin
Irinotecan hydrochloride

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