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dimethyl fumarate

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Origin: China

Cas No: 624-49-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 624-49-7 Formula: C6H8O4 Molecular Weight: 144.12500

    Description

    Dimethyl fumarate (DMF) is the methyl ester of fumaric acid. DMF was initially recognized as a very effective hypoxic cell radiosensitizer. Later, DMF combined with three other fumaric acid esters (FAE) was licensed in Germany as oral therapy for psoriasis (trade name Fumaderm). Other diseases, such as necrobiosis lipoidica, granuloma annulare, and sarcoidosis were also found to respond to treatment with DMF in case reports or small patient series. Phase III clinical trials found that DMF (BG-12) successfully reduced relapse rate and increased time to progression of disability in multiple sclerosis (trade name Tecfidera). DMF is thought to have immunomodulatory properties without significant immunosuppression.
    In a non-medical use, DMF was applied as a biocide in furniture or shoes to prevent growths of mold during storage or transport in a humid climate. However, due to incidences of allergic reactions after skin contact the European Union banned DMF in consumer products since 1998, and since January 2009 the import of products containing DMF was also banned.

    Basic Info

    Chemical Name dimethyl fumarate
    Synonyms

    2-Butenedioic acid (E)-, dimethyl ester;
    Dimethyl fumarate;

    CAS No. 624-49-7
    Molecular Formula C6H8O4
    Molecular Weight 144.12500
    PSA 52.60000
    LogP -0.11140

    Properties

    Appearance & Physical State fine white crystalline powder
    Density 1.124 g/cm3
    Boiling Point 192-193ºC
    Melting Point 102-105ºC
    Flash Point 91.1ºC
    Refractive Index 1.4037 (110.7ºC)
    Stability Stable. Incompatible with acids, bases, oxidizing agents, reducing agents.
    Storage Condition Store at RT.

    Safety Info

    RTECS EM6125000
    Safety Statements S36/37/39
    HS Code 2917140000
    WGK Germany 1
    Risk Statements R21; R36/37/38
    Hazard Codes Xn

    Synthesis Route

    dimethyl 2-(benzenesulfonamido)-3-(triphenylphosphoranylidene)butanedioate→N-(triphenyl-λ<sup>5</sup>-phosphanylidene)benzenesulfonamide+dimethyl maleate
    →Triphenylphosphine Selenide+dimethyl fumarate
    Ethyl diazoacetate+2-diazonio-1-methoxyethenolate→methyl ethyl maleic acid ester+dimethyl maleate

    Precursor

    4-(pyrrolidin-1-yl)pent-3-en-2-one
    methyl tert-butyl ether
    2-diazonio-1-methoxyethenolate
    Dimethyl acetylenedicarboxylate

    Downstream Product

    N-nitrosodiethylamine
    bis(5-methyl-2-propan-2-ylcyclohexyl) but-2-enedioate
    (-)-menthyl methyl fumarate
    TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ACID, DIMETHYL ESTER

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