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N-[4-(4-fluorophenyl)-5-methyl-6-propan-2-ylpyrimidin-2-yl]-N-methylmethanesulfonamide

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Origin: China

Cas No: 953776-62-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 953776-62-0 Formula: C16H20FN3O2S Molecular Weight: 337.41200

Description

N-[4-(4-Fluorophenyl)-5-methyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methylmethanesulfonamide is an important pyrimidine precursors for rosuvastatin synthesis.

Basic Info

Chemical Name	N-[4-(4-fluorophenyl)-5-methyl-6-propan-2-ylpyrimidin-2-yl]-N-methylmethanesulfonamide
Synonyms	N-[4-(4-Fluorophenyl)-5-methyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methylmethanesulfonamide; 5-Des-(7-carboxy-3,5-dihydroxyhept-1-enyl)-5-methyl Rosuvastatin; N-(4-(4-fluorophenyl)-6-isopropyl-5-methylpyrimidin-2-yl)-N-methylmethanesulfonamide;
CAS No.	953776-62-0
Molecular Formula	C16H20FN3O2S
Molecular Weight	337.41200
PSA	71.54000
LogP	4.19110

Synthesis Route

4-(4-fluorophenyl)-6-isopropyl-N,5-dimethylpyrimidin-2-amine+Methanesulfonyl chloride→N-[4-(4-fluorophenyl)-5-methyl-6-propan-2-ylpyrimidin-2-yl]-N-methylmethanesulfonamide
N-(4-(4-fluorophenyl)-6-isopropyl-5-((tributyl-5-phosphanylidene)methyl)pyrimidin-2-yl)-N-methylmethanesulfonamide→N-[4-(4-fluorophenyl)-5-methyl-6-propan-2-ylpyrimidin-2-yl]-N-methylmethanesulfonamide
1-(4-fluorophenyl)-4-methylpentane-1,3-dione→N-[4-(4-fluorophenyl)-5-methyl-6-propan-2-ylpyrimidin-2-yl]-N-methylmethanesulfonamide

Precursor

4-(4-fluorophenyl)-6-isopropyl-N,5-dimethylpyrimidin-2-amine
1-(4-fluorophenyl)-2-methyl-3-isopropylpropan-1,3-dione
N-(4-(4-fluorophenyl)-6-isopropyl-5-((tributyl-5-phosphanylidene)methyl)pyrimidin-2-yl)-N-methylmethanesulfonamide
Methanesulfonyl chloride

Downstream Product

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsufonyl)amino]pyrimidine-5-yl-methanol
N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide
N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide

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