Home > Organophosphorus Compounds> N-[5-(diphenylphosphorylmethyl)-4-(4-fluorophenyl)-6-propan-2-ylpyrimidin-2-yl]-N-methylmethanesulfonamide

N-[5-(diphenylphosphorylmethyl)-4-(4-fluorophenyl)-6-propan-2-ylpyrimidin-2-yl]-N-methylmethanesulfonamide

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Origin: China

Cas No: 289042-10-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
289042-10-0
Other Names:
Rosuvastatin Z-8.1
MF:
C28H29FN3O3PS
EINECS No.:
N/A
Place of Origin:
China
Type:
Pharmaceutical Intermediates, Syntheses Material Intermediates
Purity:
99%, 99%
Brand Name:
Sartort
Model Number:
APIs & Intermediates
Application:
Chemical
Appearance:
N/A
Packaging&Delivery
Packaging Details
25kg/drum
Port
Any port in china
Lead Time:
Quantity(Kilograms) 1 - 1 >1
Est. Time(days) 3 To be negotiated

Property

CAS No.: 289042-10-0 Formula: C28H29FN3O3PS Molecular Weight: 537.58500

Description

An intermediate in the production of Rosuvastatin derivatives.

Basic Info

Chemical Name	N-[5-(diphenylphosphorylmethyl)-4-(4-fluorophenyl)-6-propan-2-ylpyrimidin-2-yl]-N-methylmethanesulfonamide
Synonyms	diphenyl[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-ylmethyl]phosphine oxide; N-[5-(diphenyl-phosphinoylmethyl)-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide; diphenyl [4-(4-fluoropheny)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-ylmethyl] phosphine oxide; N-[5-[(diphenylphosphinoyl)-methyl]-4-(4-fluorophenyl)-6-isopropyl-pyrimidindin-2-yl]-N-methyl-methanesulfonamide; diphenyl[2-(N-methyl-N-methanesulfonylamino)-4-(4-fluorophenyl)-6-isopropyl-pyrimidin-5-ylmethyl]phosphine oxide; AC-3407; N-(5-((Diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide;
CAS No.	289042-10-0
Molecular Formula	C28H29FN3O3PS
Molecular Weight	537.58500
PSA	98.42000
LogP	6.39680

Properties

Density	1.322 g/cm3
Boiling Point	679.125ºC at 760 mmHg
Flash Point	364.522ºC
Refractive Index	1.625
Vapor Pressure	0mmHg at 25°C

Synthesis Route

N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide+Ethyl diphenylphosphinite→N-[5-(diphenylphosphorylmethyl)-4-(4-fluorophenyl)-6-propan-2-ylpyrimidin-2-yl]-N-methylmethanesulfonamide
Methyl 4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-carboxylate+Ethyl diphenylphosphinite→N-[5-(diphenylphosphorylmethyl)-4-(4-fluorophenyl)-6-propan-2-ylpyrimidin-2-yl]-N-methylmethanesulfonamide
Chlorodiphenylphosphine+4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsufonyl)amino]pyrimidine-5-yl-methanol→N-[5-(diphenylphosphorylmethyl)-4-(4-fluorophenyl)-6-propan-2-ylpyrimidin-2-yl]-N-methylmethanesulfonamide

Precursor

Ethyl diphenylphosphinite
4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsufonyl)amino]pyrimidine-5-yl-methanol
N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide
Chlorodiphenylphosphine

Downstream Product

tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate
Rosuvastatin Lactone

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