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1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride

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Origin: China

Cas No: 51-02-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 51-02-5 Formula: C15H20ClNO Molecular Weight: 265.77800

Description

Pronethalol (Alderlin, Nethalide) was an early non-selective beta blocker clinical candidate. It was never used clinically due to carcinogenicity in mice, which was thought to result from formation of a carcinogenic naphthalene epoxide metabolite.

Basic Info

Chemical Name	1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride
Synonyms	DL-Pronethalol hydrochloride; Alderlin hydrochloride; Pronetalol hydrochloride; PRONETHALOL HYDROCHLORIDE; Nethalide hydrochloride; Pronethalol.HCl; Naphthylisoproterenol hydrochloride;
CAS No.	51-02-5
Molecular Formula	C15H20ClNO
Molecular Weight	265.77800
PSA	32.26000
LogP	4.06410

Properties

Density	1.074g/cm3
Boiling Point	322.4ºC at 760mmHg
Flash Point	84.3ºC
Refractive Index	1.596
Storage Condition	Store at RT

Safety Info

HS Code	2922199090

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	425 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	102 mg/kg	1.Behavioral-somnolence (general depressed activity) 2.Behavioral-convulsions or effect on seizure threshold 3.Lungs, Thorax, or Respiration-respiratory stimulation
Intravenous	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	35 mg/kg	1.Details of toxic effects not reported other than lethal dose value