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phenylephrine

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Origin: China

Cas No: 59-42-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

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Product Description

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CAS No.: 59-42-7 Formula: C9H13NO2 Molecular Weight: 167.20500

Description

Phenylephrine is a selective α1-adrenergic receptor agonist of the phenethylamine class used primarily as a decongestant, as an agent to dilate the pupil, and to increase blood pressure. Phenylephrine is marketed as an alternative for the decongestant pseudoephedrine, although clinical trials show phenylephrine, taken orally at the recommended dose, to be no more effective than placebo. Phenylephrine can also cause a decrease in heart rate through reflex bradycardia.

Basic Info

Chemical Name	phenylephrine
Synonyms	Neophryn; Mydfrin; Mesatone; Mesaton; Phenylephrine; Nostril; Mezaton; Adrianol; Isophrin; Prefrin;
CAS No.	59-42-7
Molecular Formula	C9H13NO2
Molecular Weight	167.20500
PSA	52.49000
LogP	1.03590

Properties

Density	1.159 g/cm3
Boiling Point	341.1ºC at 760 mmHg
Melting Point	171ºC
Flash Point	163.4ºC
Refractive Index	-55.5 ° (C=5, 1mol/L HCl)

Safety Info

RTECS	DO7175000
Safety Statements	26-36-45
Risk Statements	R22

Synthesis Route

1-(3-hydroxyphenyl)-2-(methylamino)ethanone,hydrochloride→(+)-Phenylephrine+phenylephrine
(R)-phenylephrine-(R)-naproxen→phenylephrine
(+)-Phenylephrine→phenylephrine

GC Analysis

Column type	Active phase	Temperature (°C)	Retention Index (I)	Temperature Control Method
Packed	SE-30	-	1660.	temperature ramp
Other	Methyl Silicone	-	1660.	custom temperature program

Precursor

3-Methoxybenzaldehyde
9-Brom-10-azido-9.10-dihydrophenanthren
(R)-phenylephrine-(R)-naproxen
1-(3-hydroxyphenyl)-2-(methylamino)ethanone,hydrochloride

Downstream Product

phenylephrine hydrochloride
(R)-5-(3-Hydroxyphenyl)-3-methyl-2-oxazolidinone

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