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L-(-)-α-Methyldopa

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Origin: China

Cas No: 555-30-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
555-30-6
Other Names:
Methyldopa
MF:
C10H13NO4
EINECS No.:
209-089-2
Place of Origin:
Shandong, China
Type:
Anesthetic Agents
Grade Standard:
Medicine Grade
Usage:
Animal Pharmaceuticals
Brand Name:
QDXIGEMA
Model Number:
top
Purity:
99%
Product Name:
Methyldopa
MW:
211.21
Melting point:
≥300 °C
Boiling point:
350.89°C (rough estimate)
density:
1.2545 (rough estimate)
refractive index:
-14 ° (C=1, H2O)
storage temp:
Store at RT
Merck:
14,6055
Shelf life:
2 years
Packaging&Delivery
Packaging Details
1kg/drum 5kg/drum, 10kg/drum,25kg/drum
Port
Qingdao port

Property

CAS No.: 555-30-6 Formula: C10H13NO4 Molecular Weight: 211.21500

Description

Methyldopa (L-α-Methyl-3,4-dihydroxyphenylalanine; Aldomet, Aldoril, Dopamet, Dopegyt, etc.) is a centrally acting antihypertensive agent. It is metabolized to alpha-methylnorepinephrine in the brain, and this compound is thought to activate central alpha-2 adrenergic receptors (Gerber, 1990). Being a selective agonist for α2 adrenergic receptors, psychoactive drug is used as a sympatholytic or antihypertensive. Its use is now mostly deprecated following the introduction of alternative safer classes of agents. However, it continues to have a role in otherwise difficult to treat hypertension and gestational hypertension (previously known as pregnancy-induced hypertension (PIH)).
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

Basic Info

Chemical Name	L-(-)-α-Methyldopa
Synonyms	Methyldopa Sesquihydrate; Methyldopa; alpha-methyl-L-dopa; α-methyl-L-dopa; L-Tyrosine, 3-hydroxy-α-methyl-;
CAS No.	555-30-6
Molecular Formula	C10H13NO4
Molecular Weight	211.21500
PSA	103.78000
LogP	1.14260

Properties

Appearance & Physical State	Colorless or almost colorless crystals or white to yellowish-white fine powder. Almost tasteless. In the sesquihydrate form.
Density	1.403g/cm3
Boiling Point	441.6ºC at 760mmHg
Melting Point	300ºC
Flash Point	220.9ºC
Refractive Index	-14 ° (C=1, H2O)
Water Solubility	Soluble
Soluble	Soluble in DMSO (75 mM), water, and dilute hydrochloric acid.
Stability	Stable under normal temperatures and pressures.
Storage Condition	Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.

Safety Info

RTECS	YP2860000
Safety Statements	S24/25
HS Code	2918199090
WGK Germany	3

Synthesis Route

4-(bromomethyl)-1,2-dimethoxybenzene→L-(-)-α-Methyldopa
dimethyl 2-(3,4-dimethoxybenzyl)-2-methylmalonate→L-(-)-α-Methyldopa
→L-(-)-α-Methyldopa

Precursor

dimethyl 2-(3,4-dimethoxybenzyl)-2-methylmalonate

N-Chloroacetyl-D-α-methyl-DOPA
(2S,5S)-1-benzoyl-2-(tert-butyl)-5-(3',4'-dimethoxybenzyl)-3,5-dimethylimidazolidin-4-one

Downstream Product

[(2R,3R,4R)-5-acetyloxy-3,4-dibenzoyloxyoxolan-2-yl]methyl benzoate
methyl-2 [(tri-O-benzoyl-2',3',5' β-D-ribofuranosyl)-3 hydroxy-4 phenyl]-3 alanine
2-methyl-1H-indole-5,6-diol
N-acetyltri-O-benzoyl-α-D-xylofuranosylamine

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