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3-(dithiophen-2-ylmethylidene)-1-methylpiperidine

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Origin: China

Cas No: 5169-78-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 5169-78-8 Formula: C15H17NS2 Molecular Weight: 275.43200

Description

Tipepidine (INN) (brand names Asverin, Antupex, Asvelik, Asvex, Bitiodin, Cofdenin A, Hustel, Nodal, Sotal), also known as tipepidine hibenzate (JAN), is a synthetic, non-opioid antitussive and expectorant of the thiambutene class. It acts as an inhibitor of G protein-coupled inwardly-rectifying potassium channels (GIRKs). The drug was discovered in the 1950s, and was developed in Japan in 1959. It is used as the hibenzate and citrate salts.
The usual dose is 20mg every 4–6 hours. Possible side effects of tipepidine, especially in overdose, may include drowsiness, vertigo, delirium, disorientation, loss of consciousness, and confusion.
Tipepidine has recently garnered interest as a potential psychiatric drug. It is being investigated in depression, obsessive-compulsive disorder, and attention-deficit hyperactivity disorder (ADHD). Through inhibition of GIRK channels, tipepidine increases dopamine levels in the nucleus accumbens, but without increasing locomotor activity or producing methamphetamine-like behavioral sensitization, and this action appears to be at least partly responsible for its antidepressant-like effects in rodents.

Basic Info

Chemical Name	3-(dithiophen-2-ylmethylidene)-1-methylpiperidine
Synonyms	Bitiodin; 3-(di-thiophen-2-yl-methylene)-1-methyl-piperidine; (1-Methyl-3-piperidyliden)di-2-thienylmethan-embonat; 3-(Di-[2]thienyl-methylen)-1-methyl-piperidin; Tipepidinum [INN-Latin]; CR/662; Piperidine, 3-(di-2-thienylmethylene)-1-methyl-; AT 327; Tipepidine; Tipepidina [INN-Spanish]; Asverin; (1-Methyl-3-piperidylidene)di(2-thienyl)methane; 3-(di-[2]thienyl-methylene)-1-methyl-piperidine; Tipepidine [INN:DCF]; Tipedine;
CAS No.	5169-78-8
Molecular Formula	C15H17NS2
Molecular Weight	275.43200
PSA	59.72000
LogP	4.27500

Safety Info

HS Code	2934999090

Synthesis Route

(1-methyl-piperidin-3-yl)-di-thiophen-2-yl-methanol→3-(dithiophen-2-ylmethylidene)-1-methylpiperidine
2-Bromothiophene+1-Methyl-Piperidine-3-Carboxylic Acid Methyl Ester→3-(dithiophen-2-ylmethylidene)-1-methylpiperidine

GC Analysis