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chloramphenicol

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Origin: China

Cas No: 56-75-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 56-75-7 Formula: C11H12Cl2N2O5 Molecular Weight: 323.12900

Description

Broad spectrum antibiotic obtained from cultures of the soil bacterium Streptomyces venezuelae. It has a broad spectrum of activity against Gram-positive and gram-negative bacteria. Antibacterial; antirickettsial.

Basic Info

Chemical Name	chloramphenicol
Synonyms	chloroamphenicol; D-(?)-threo-1-p-nitrophenyl-2-dichloracetamido-1,3-propanediol; 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide; Ambofen; Enicol; CAF; Catilan; i337a; Chloramphenicol; u-6062; Chlomin; Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-, [R-(R,R)]-; Mychel; 2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide;
CAS No.	56-75-7
Molecular Formula	C11H12Cl2N2O5
Molecular Weight	323.12900
PSA	115.38000
LogP	1.82310

Properties

Appearance & Physical State	white to off-white crystalline powder
Density	1.547 g/cm3
Boiling Point	644.9ºC at 760 mmHg
Melting Point	149-153ºC
Flash Point	343.8ºC
Refractive Index	20 ° (C=5, EtOH)
Water Solubility	2.5 g/L (25 º C)
Stability	Stable under normal shipping and handling conditions.
Storage Condition	2-8ºC

Safety Info

RTECS	AB6825000
Safety Statements	S45-S53
HS Code	2941400000
WGK Germany	3
RIDADR	UN 1851
Risk Statements	R45
Hazard Codes	T

Synthesis Route

(2'R,3'R)-chloramphenicol 1',3'-diacetate→chloramphenicol
(2S)-(2,2-dichloroacetylamino)-(3R)-hydroxy-3-(4-nitrophenyl)-propionic acid ethyl ester→chloramphenicol
Dichloroacetic acid methyl ester+1-(p-Nitrophenyl)-2-amino-1,3-propanediol→chloramphenicol

GC Analysis

Column type	Active phase	Temperature (°C)	Retention Index (I)	Temperature Control Method
Packed	SE-30	-	2310.	temperature ramp
Other	Methyl Silicone	-	2310.	custom temperature program

Precursor

(2S)-(2,2-dichloroacetylamino)-(3R)-hydroxy-3-(4-nitrophenyl)-propionic acid ethyl ester
1-(p-Nitrophenyl)-2-amino-1,3-propanediol
(2'R,3'R)-chloramphenicol 1',3'-diacetate
Dichloroacetic acid methyl ester

Downstream Product

chloramphenicol palmitate
4-nitrobenzaldehyde

4-[(2R,3R)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propoxy]-4-oxobutanoic acid

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