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fluocinolone acetonide

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Origin: China

Cas No: 67-73-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
67-73-2
Other Names:
Fluocinolone Acetonide
MF:
C24H30F2O6
EINECS No.:
200-668-5
Place of Origin:
Hebei, China
Type:
Auxiliaries and Other Medicinal Chemicals
Grade Standard:
Medicine Grade
Usage:
Animal Pharmaceuticals
Brand Name:
Crovell
Model Number:
67-73-2
Purity:
99%
Product Name:
Fluocinolone Acetonide
CAS:
67-73-2
Molecular Weight:
178.18
Melting point:
173.5 °C(lit.)
Packaging&Delivery
Packaging Details
67-73-2 1KG /5KG/10KG/25KG/50KG BAG
Port
67-73-2 SHIJIAZHUANG
Lead Time:
Quantity(Grams) 1 - 1000 >1000
Est. Time(days) 2 To be negotiated

Property

CAS No.: 67-73-2 Formula: C24H30F2O6 Molecular Weight: 452.48800

Description

Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. It was first synthesized in 1959 in the Research Department of Syntex Laboratories S.A. Mexico City. Preparations containing it were first marketed under the name Synalar. A typical dosage strength used in dermatology is 0.01–0.025%. One such cream is sold under the brand name Flucort-N and includes the antibiotic neomycin.
Fluocinolone acetonide was also found to strongly potentiate TGF-β-associated chondrogenesis of bone marrow mesenchymal stem/progenitor cells, by increasing the levels of collagen type II by more than 100 fold compared to the widely used dexamethasone.
Fluocinolone acetonide intravitreal implants have been used to treat non-infectious uveitis. A systematic review could not determine whether fluocinolone acetonide implants are superior to standard of care treatment for uveitis.
Flucinolone is a group V (0.025%) or group VI (0.01%) corticosteroid under US classification.

Basic Info

Chemical Name	fluocinolone acetonide
Synonyms	Fluocinolone acetonide;
CAS No.	67-73-2
Molecular Formula	C24H30F2O6
Molecular Weight	452.48800
PSA	93.06000
LogP	2.36680

Properties

Appearance & Physical State	Crystalline Solid
Density	1.36g/cm3
Boiling Point	579ºC
Melting Point	267-269ºC
Refractive Index	103 ° (C=1, MeOH)
Storage Condition	Keep tightly closed. Store in a cool dry place.

Safety Info

RTECS	TU3830000
Safety Statements	S22-S26-S36
HS Code	2937210000
WGK Germany	3
Risk Statements	R20/21/22; R36/37/38; R40
Hazard Codes	Xn

Synthesis Route

21-O-acetyl 1,2-dihydrofluocinolone acetonide→fluocinolone acetonide
Ethanol+fluocinolone acetonide 21-(2'-phenoxypropionate)→fluocinolone acetonide+ethyl 2-phenoxy-propionate
Fluocinolone Acetonide Acetate→fluocinolone acetonide

Precursor

Ethanol
fluocinolone acetonide 21-(2'-ethoxypropionate)
Fluocinolone Acetonide Acetate
fluocinolone acetonide 21-(2'-phenoxypropionate)

Downstream Product

UNII-00K9NWZ23G
Fluocinolone Acetonide Acetate
UNII-QUA72C1T6F

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