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nobiletin

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Origin: China

Cas No: 478-01-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 478-01-3 Formula: C21H22O8 Molecular Weight: 402.39500

    Description

    Nobiletin is a flavonoid isolated from citrus peels. It is an O-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment.

    Basic Info

    Chemical Name nobiletin
    Synonyms

    Nobiletin,Hexamethoxyflavone;
    2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one;
    3',4',5,6,7,8-hexamethoxy-flavone;
    Nobiletin;
    5,6,7,8,3',4'-Hexamethoxyflavone;
    3',4',5,6,7,8-Hexamethoxyflavone;
    Hexamethoxyflavone;
    2-(3,4-dimethoxy-phenyl)-5,6,7,8-tetramethoxy-chromen-4-one;

    CAS No. 478-01-3
    Molecular Formula C21H22O8
    Molecular Weight 402.39500
    PSA 85.59000
    LogP 3.51160

    Properties

    Density 1.244g/cm3
    Boiling Point 587.9ºC at 760mmHg
    Flash Point 256.5ºC
    Refractive Index 1.558
    Stability Stable, but unstable if heated rapidly. Combustible. Incompatible with strong oxidizing agents, powdered aluminium, potassium.
    Vapor Pressure 8.39E-14mmHg at 25°C

    Safety Info

    Safety Statements S26; S36/37/39
    Risk Statements R36/37/38

    Synthesis Route

    1-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1,3-propanedione→nobiletin
    5,8-dihydroxy-6,7-dimethoxy-2-(3,4-dimethoxyphenyl)-4-benzopyrone+dimethyl sulfate→nobiletin
    1-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)ethanone→nobiletin

    Precursor

    1-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)ethanone
    3,4-DIMETHOXYBENZOYL CHLORIDE
    1-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1,3-propanedione
    5,8-dihydroxy-6,7-dimethoxy-2-(3,4-dimethoxyphenyl)-4-benzopyrone

    Downstream Product

    2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxychromen-4-one
    5-hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one
    2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7-trimethoxychromen-4-one
    gardenin B

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