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3-O-ethyl 5-O-methyl 2-(2-azidoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

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Origin: China

Cas No: 88150-46-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 88150-46-3 Formula: C20H23ClN4O5 Molecular Weight: 434.87300

Description

An impurity arising in the synthesis of amlodipine.

Basic Info

Chemical Name	3-O-ethyl 5-O-methyl 2-(2-azidoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Synonyms
CAS No.	88150-46-3
Molecular Formula	C20H23ClN4O5
Molecular Weight	434.87300
PSA	123.61000
LogP	3.39946

Synthesis Route

Methyl 2-(2-chlorobenzylidene)-3-oxobutanoate→3-O-ethyl 5-O-methyl 2-(2-azidoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
2-azidoethyl ethyl malonate+2-Chlorobenzaldehyde→3-O-ethyl 5-O-methyl 2-(2-azidoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
methyl (2Z)-2-[(2,3-dichlorophenyl)methylidene]-3-oxobutanoate→3-O-ethyl 5-O-methyl 2-(2-azidoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate+2-(2-azidoethoxy)methyl-4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

Precursor

Methyl 2-(2-chlorobenzylidene)-3-oxobutanoate
methyl (2Z)-2-[(2,3-dichlorophenyl)methylidene]-3-oxobutanoate
2-Chlorobenzaldehyde
Methyl 3-aminocrotonate

Downstream Product

Amlodipine maleate
amlodipine

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