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dimethyl 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

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Origin: China

Cas No: 71653-63-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 71653-63-9 Formula: C18H19F2NO5 Molecular Weight: 367.34400

Description

Riodipine (INN) (brand names Foridon, Ryosidine) is a calcium channel blocker.

Basic Info

Chemical Name	dimethyl 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Synonyms	Riodipinum [Latin]; Ryodipine; 2,6-Dimethyl-3,5-dimethoxycarbonyl-4-(ortho-difluoromethoxyphenyl)-1,4-dihydropyridine; Riodipine [INN]; Foridon; Riodipine; 2,6-Dimethyl-3,5-dimethoxycarbonyl-4-(o-difluoromethoxyphenyl)-1,4-dihydropyridine; PP-1466; Riodipino [Spanish];
CAS No.	71653-63-9
Molecular Formula	C18H19F2NO5
Molecular Weight	367.34400
PSA	73.86000
LogP	3.19760

Properties

Density	1.242g/cm3
Boiling Point	445.4ºC at 760 mmHg
Flash Point	223.2ºC
Refractive Index	1.509

Synthesis Route

2-(Difluoromethoxy)benzaldehyde+Methyl acetoacetate→dimethyl 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Precursor

2-(Difluoromethoxy)benzaldehyde
Methyl acetoacetate

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