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3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

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Origin: China

Cas No: 89226-50-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 89226-50-6 Formula: C35H38N4O6 Molecular Weight: 610.69900

Description

A dihydropyridine calcium channel blocker. Antihypertensive.

Basic Info

Chemical Name	3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Synonyms	MANIDIPINE: MANIDIPINE DIHYDROCHLORIDE; 1-diphenylmethyl-4-(2-hydroxyethyl)piperazine; 3-{2-[4-(diphenylMethyl)piperazin-1-yl]ethyl} 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; Manidipine 6300; Manidipine; CV-4093,2-(4-diphenylmethyl-1-piperazinyl)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate; Manidipine (Manyper); 2-(4-(Diphenylmethyl)-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; (+/-)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester; 2-(4-Diphenylmethyl-1-piperazinyl)ethyl methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate; 2-(4-benzhydryl-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; Franidipine;
CAS No.	89226-50-6
Molecular Formula	C35H38N4O6
Molecular Weight	610.69900
PSA	116.93000
LogP	5.68080

Properties

Density	1.232 g/cm3
Boiling Point	722ºC at 760 mmHg
Melting Point	125-128ºC
Flash Point	390.4ºC
Storage Condition	-20ºC Freezer

Synthesis Route

2-[4-(Diphenylmethyl)-1-piperazinyl]ethanol+5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid→3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
3-Nitrobenzaldehyde+2-(4-benzhydrylpiperazin-1-yl)ethyl 3-oxobutanoate→3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
2-[4-(Diphenylmethyl)-1-piperazinyl]ethanol→3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Precursor

5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid
3-Nitrobenzaldehyde
2-(4-benzhydrylpiperazin-1-yl)ethyl 3-oxobutanoate
2-[4-(Diphenylmethyl)-1-piperazinyl]ethanol

Downstream Product

Manidipine Dihydrochloride

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